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Dopamine

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Dopamine appear to play a central role in cost-benefit analysis[1]. There appear to be multiple dopamine-sensitive decision regions.

Dopamine depletion in ventral striatum reduces propensity for physical effort [2] D1 (dopamine 1) receptor blockade in ACC reduces preference for expending effort for rats[3].

References

  1. Phillips PEM, Walton ME, Jhou TC. Calculating utility: Preclinical evidence for cost– benefit analysis by mesolimbic dopamine. Psychopharmacology. 2007;191: 483– 495.
  2. Salamone JD, Correa M, Farrar A, Mingote SM. Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology. 2007;191: 461– 482.
  3. Schweimer J, Hauber W. Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision-making. Learning & Memory. 2006;13: 777–782