3,078
edits
Changes
no edit summary
Dopamine appear to play a central role in cost-benefit analysis<ref>Phillips PEM, Walton ME, Jhou TC. Calculating utility: Preclinical evidence for cost– benefit analysis by mesolimbic dopamine. Psychopharmacology. 2007;191: 483– 495.</ref>. There appear to be multiple dopamine-sensitive decision regions.
[[Dopamine|Dopamine]] depletion in [[Ventral stratium|ventral striatum]] reduces propensity for physical effort <ref>Salamone JD, Correa M, Farrar A, Mingote SM. Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology. 2007;191: 461– 482.</ref> D1 ([[dopamine]] 1) receptor blockade in [[ACC]] reduces preference for expending effort for rats<ref>Schweimer J, Hauber W. Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision-making. Learning & Memory. 2006;13: 777–782</ref>.It is non-discriminative between reward types, dopaminergic firing in [[VTA]] does appear to reflect subjective (action) value with integrated responses to both delay and reward amount<ref>Roesch MR, Calu DJ, Schoenbaum G. Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewards. Nature Neuroscience. 2007;10: 1615– 1624.</ref>.
==References==