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In old age the is decline in RPE<ref>Eppinger, Ben, et al. "Reduced Striatal Responses to Reward Prediction Errors in Older Compared with Younger Adults." The Journal of Neuroscience 33.24 (2013): 9905-9912.</ref>, but usage of L-dopa can increase the RPE again<ref>[http://www.variational-bayes.org/~qhuys/pub/ChowdhuryEa13-DAValue.pdf Chowdhury, Rumana, et al. "Dopamine restores reward prediction errors in old age." Nature neuroscience (2013).]</ref>
RPE can cause pupil dilation in the case of risk error prediction<ref>[ Preuschoff, K., Marius’t Hart, B., & Einhäuser, W. (2011). Pupil dilation signals surprise: evidence for noradrenaline’s role in decision making. Frontiers in neuroscience, 5.
ISO 690]</ref>
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