3,078
edits
Changes
no edit summary
The LC's role in cognitive function in relation to stress is complex and multi-modal. Norepinephrine released from the LC can act on α2 receptors to increase working memory, or an excess of NE may decrease working memory by binding to the lower-affinity α1 receptors.<ref name="Ramos">Ramos BP, Arnsten AF. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacol Ther 2007; 113: 523-536.</ref>
LC-NE and [[ACC]] may modulate [[attention|aroused attention]] in a novel environment and new social environment<ref>Heinrich S Gompf, Christine Mathai, Patrick M Fuller, David A Wood, Nigel P Pedersen, Clifford B Saper, and Jun Lu, 2011, Locus coeruleus (LC) and anterior cingulate cortex sustain wakefulness in a novel environment, Neurosci. Oct 27, 2010; 30(43): 14543–14551.</ref>. There is a strong corrolation between CL firing and wakefulness levels. LC neural activity is highest during wakefulness, progressively lower during non-rapid eye movement (REM) sleep, and nearly absent during REM sleep<ref>Aston-Jones G, Bloom FE (1981) Activity of norepinephrine-containing locus coeruleus neurons in behaving rats anticipates fluctuations in the sleep-waking cycle. J Neurosci 1:876–886.</ref>
==References==