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Dopamine agonists can cause pathological gambling behavior<ref>Gallagher DA, O’Sullivan SS, Evans AH, Lees AJ, Schrag A. Pathological gambling in Parkinson’s disease: Risk factors and differences from dopamine dysregulation An analysis of published case series. Movement Disorders. 2007;22: 1757– 1763.</ref><ref>Agnes Norbury, Sanjay Manohar, Robert D. Rogers and Masud Husain,, 2013, Dopamine Modulates [[risk taking|Risk Taking]] as a Function of Baseline Sensation-Seeking Trait, The Journal of Neuroscience, 7 August 2013, 33(32):12982-12986</ref>. This finding is in support of the theory that people with less [[rewards]] will try to enhance the rewards, by taking more risks.
Genetic polymorphisms affecting DRD2 receptor expression alter neuronal responses to food [[rewards|reward]]<ref>Felsted JA, Ren X, Chouinard-Decorte F, Small DM. Genetically determined differences in brain response to a primary food reward. Journal of Neuroscience. 2010;30: 2428– 2432.</ref>
DRD4 polymorphisms modulate the incentive [[value]] of alcohol in alcoholics<ref>MacKillop J, Menges DP, McGeary JE, Lisman SA. Effects of craving and DRD4 VNTR genotype on the relative value of alcohol: An initial human laboratory study. Behavioral and Brain Functions. 2007;3: 11</ref>