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Dopamine appear to play a central role in cost-benefit analysis<ref>Phillips PEM, Walton ME, Jhou TC. Calculating utility: Preclinical evidence for cost– benefit analysis by mesolimbic dopamine. Psychopharmacology. 2007;191: 483– 495.</ref>. There appear to be multiple dopamine-sensitive decision regions.
[[Dopamine|Dopamine]] depletion in [[Ventral stratium|ventral striatum]] reduces propensity for physical effort <ref>Salamone JD, Correa M, Farrar A, Mingote SM. Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits. Psychopharmacology. 2007;191: 461– 482.</ref>