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DACC

4,204 bytes added, 08:12, 18 December 2014
Created page with "Hypotheses about its function include guiding reward-based decision making<ref>illiams, Z. M., Bush, G., Rauch, S. L., Cosgrove, G. R. & Eskandar, E. N. Human anterior cingula..."
Hypotheses about its function include guiding reward-based decision making<ref>illiams, Z. M., Bush, G., Rauch, S. L., Cosgrove, G. R. & Eskandar, E. N. Human anterior cingulate neurons and the integration of monetary reward with motor responses. Nature Neurosci.7, 1370–1375 (2004).</ref>, monitoring for conflict between competing responses<ref>otvinick, M., Nystrom, L. E., Fissell, K., Carter, C. S. & Cohen, J. D. Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 402, 179–181 (1999)</ref> and predicting task difficulty<ref>rown, J. W. & Braver, T. S. Learned predictions of error likelihood in the anterior cingulate cortex. Science 307,
1118–1121 (2005)</ref>. Precise mechanisms of dACC function remain unknown. It was found that dACC is involved in adapting behaviour.<ref>[http://ziv.mgh.harvard.edu/pdf/nature11239.pdf Sheth, Sameer A., Matthew K. Mian, Shaun R. Patel, Wael F. Asaad, Ziv M. Williams, Darin D. Dougherty, George Bush, and Emad N. Eskandar. "Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation." Nature (2012).]</ref>.


It is thought that the dorsal ACC is primarly involved in cognitive processing<ref>Bush G, Luu P & Posner MI, Cognotve and emotional influances in the anterior cingulate cotrex, Trends. Cogn. Sci. 4, 215-222 (2000)</ref>. It is part of the learning mechanism, that learn the positive and negative outcomes of actions in neutral tasks<ref>Botvinick M; Nystrom LE; Fissell K; Carter CS; Cohen JD: Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 1999; 402:179—181</ref><ref>Kerns JG; Cohen JD; MacDonald AW 3rd; Cho RY; Stenger VA; Carter CS: Anterior cingulate conflict monitoring and adjustments in control. Science 2004; 303:1023—1026</ref><ref>Carter CS; Macdonald AM; Botvinick M; Ross LL; Stenger VA; Noll D; Cohen JD: Parsing executive processes: strategic vs evaluative functions of the anterior cingulate cortex. Proc Natl Acad Sci USA 2000; 97:1944—1948</ref><ref>Egner T; Hirsch J: The neural correlates and functional integration of cognitive control in a Stroop task. Neuroimage 2005; 24:539—547</ref> and with correlation with rostral ACC, it is involved in emotional learning. It is also a reward mechanism, that gives "globals enrgizing factor", to actions that in the past seems to be rewarding<ref>Struss DT et al.,2005, Multiple frontal systems controlling response speed, ''Neuropshichologia'', 43: 396-417</ref>. Rats with lisions in the ACC, prefer less effortful mission with less reward, to tasks with more effortful with more reward<ref>Walton ME at al, 2003, Fanctional specilization within medial frontal cortex of the antirior cingulate for evaluating effort-related decisions, ''J Neurosci'', 23: 6475-6479</ref>.The ACC motivation mechanism is dependent on dopamin<ref>Assadi SM, Yucel M & Pantelis C, 2009, Dopamin Modulates neural netowrks involved in effort-based decision making, ''Neurosci Biobehav'', 33: 383-393</ref><ref>Alexander MP, 2001, Chronic akinetic mutism after mesanphilic-diancphelick infraction: remediated with dopaminergic medications, ''Neurohabil Nural Repai'', 15:151-156</ref>. The Meutation in Dopamin receptor D2 may lower the amount of dopamin recived by the ACC, thus it may be the cause that make people with Atention Deficit Disorder ([[ADD]]), have lack of motivation to engage in effortful actions and decision making.

[[A Role for the Human Dorsal Anterior Cingulate Cortex in Fear Expression, 2007]] - dACC has a major role in [[fear]] expression. When electrode stimulus was introduced to the dACC during head operations, patients reported high level of anxiety, where as when the regions was removed, anxiety symptoms were reduced<ref>Meyer G, McElhaney M, Martin W, McGraw CP (1973): Stereotactic cin- gulotomy with results of acute stimulation and serial psychological testing, In: Laitinen LV, Livingston KE, editors. Surgical Approaches in Psychiatry. Lancaster, United Kingdom: MTP, Baltimore, 39 –58.</ref>. See also the page on [[fear]].

[[Dorsal ACC decision making system]]

==References==
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