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→LC and Novel Environmental Stimuli
LC neurons do respond vigorously to novel environmental stimuli<ref>Vankov A, Hervé-Minvielle A, Sara SJ (1995) Response to novelty and its rapid habituation in locus coeruleus neurons of the freely exploring rat. Eur J Neurosci 7:1180–1187.</ref>. A more causal link was found when fharmacological inhibition of LC transmission impaired exploratory behavior<ref>Sara SJ, Dyon-Laurent C, Hervé A (1995) Novelty seeking behavior in the rat is dependent upon the integrity of the noradrenergic system. Brain Res Cogn Brain Res 2:181–187</ref>.
LC innervation provides the [[cerebral cortex]] including the [[ACC]] with [[noradrenaline]] during times of elevated arousal and focused attention<ref>Aston-Jones G, Cohen JD (2005) An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu Rev Neurosci 28:403–450.</ref>. It seems that [[LC-NE system|LC-NE]] relese [[Norepinephrine]] to [[ACC]], which then elvate wakeness. The [[ACC]] send signals to the [[LC-NE system|LC]], to maintain wakeness while new stimules are precived<ref>Heinrich S. Gompf, Christine Mathai, Patrick M. Fuller, David A. Wood, Nigel P. Pedersen, Clifford B. Saper, and Jun Lu (2010) Locus Ceruleus and Anterior Cingulate Cortex Sustain Wakefulness in a Novel Environment, The Journal of Neuroscience, 27 October 2010, 30(43): 14543-14551</ref>
==References==