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→LC and Novel Environmental Stimuli
===LC and Novel Environmental Stimuli===
LC neurons do respond vigorously to novel environmental stimuli<ref>Vankov A, Hervé-Minvielle A, Sara SJ (1995) Response to novelty and its rapid habituation in locus coeruleus neurons of the freely exploring rat. Eur J Neurosci 7:1180–1187.</ref>. A more causal link was found when fharmacological inhibition of LC transmission impaired exploratory behavior<ref>Sara SJ, Dyon-Laurent C, Hervé A (1995) Novelty seeking behavior in the rat is dependent upon the integrity of the noradrenergic system. Brain Res Cogn Brain Res 2:181–187</ref>.
LC innervation provides the [[cerebral cortex]] including the [[ACC]] with [[noradrenaline]] during times of elevated arousal and focused attention<ref>Aston-Jones G, Cohen JD (2005) An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance. Annu Rev Neurosci 28:403–450.</ref>
==References==