3,078
edits
Changes
ACC
,no edit summary
The '''anterior cingulate cortex''' (ACC) is the frontal part of the [[cingulate cortex]], that resembles a "collar" form around the [[corpus callosum]], the fibrous bundle that relays neural signals between the right and left [[cerebral hemisphere]]s of the brain. It consists of Brodmann areas 24, 32 and 33. It appears to play a role in a wide variety of [[Autonomic nervous system|autonomic]] functions, such as regulating blood pressure and heart rate, as well as rational cognitive functions, such as [[rewards|reward]] anticipation, [[Decision Making|decision making]], empathy<ref>http://ccare.stanford.edu/node/89</ref> and emotion.<ref>Decety, J., & Jackson, P.L. (2004). The functional architecture of human empathy. Behavioral and Cognitive Neuroscience Reviews, 3, 71-100.</ref><ref>Jackson P.L., Brunet E., Meltzoff A.N., Decety J., 2006 Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain: An event-related fMRI study, ''Neuropsychologia'', 44, pp. 752–61</ref>.ACC gyrus is involved in learning social values<ref>Rushworth M, Behrens T, Rudebeck P, Walton M. Contrasting roles for cingulate and orbitofrontal cortex in decisions and social behavior. Trends In Cognitive Sciences. 2007;11: 168– 176.</ref>. ACC sulcus may be required for learning of [[action]] [[value|values]]<ref>Kennerley SW, Walton ME, Behrens TEJ, Buckley MJ, Rushworth MFS. Optimal decision-making and the anterior cingulate cortex. Nature Neuroscience. 2006;9: 940– 947.</ref>. Similar regions in ACC have also been shown to encode decision uncertainty<ref>Behrens TE, Woolrich MW, Walton ME, Rushworth MF. Learning the value of information in an uncertain world. Nature Neuroscience. 2007;10: 1214–1221.</ref>
In decision making it is thought to detect conflicts between two deductions<ref>[http://www.nature.com/neuro/journal/v10/n10/abs/nn1979.html Neurocognitive correlates of liberalism and conservatism, 2007, Amodio et al. Nature neuroscience] ([http://www.talyaron.com/wiki/index.php?title=Neurocognitive_correlates_of_liberalism_and_conservatism_2007 Summery in Hebrew])</ref><ref>[http://cercor.oxfordjournals.org/content/18/4/796.full Jin Fan, Patrick R. Hof, Kevin G. Guise, John A. Fossella and Michael I. Posner, The Functional Integration of the Anterior Cingulate Cortex during Conflict Processing, Cerebral Cortex, Volume 18 Issue 4, p. 796-805.]</ref> and [[value evaluation in the brain|evaluating]] the [[rewards]] of actions<ref>[http://www.nature.com/neuro/journal/v9/n7/abs/nn1724.html Kennerley et al., Optimal decision making and the anterior cingulate cortex, Nature Neuroscience 9, 940 - 947 (2006)] </ref>. On the integration of these finding please read this [http://www.lamsade.dauphine.fr/~mousseau/pmwiki-2.1.5/uploads/Bibliographie/13.pdf article].D1 ([[dopamine]] 1) receptor blockade in ACC reduces preference for expending effort for rats<ref>Schweimer J, Hauber W. Dopamine D1 receptors in the anterior cingulate cortex regulate effort-based decision-making. Learning & Memory. 2006;13: 777–782</ref>.