[[seratonine|Seratonine]] deplition<ref>Denk F, Walton M, Jennings K, Sharp T, Rushworth M, Bannerman D. Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort. Psychopharmacology. 2005;179: 587– 596.</ref> and [[NMDA]] antagonism <ref>Floresco SB, Tse MTL, Ghods-Sharifi S. Dopaminergic and glutamatergic regulation of effort-and delay-based decision-making.</ref>promote impulsivity  ==Actions - Anticepation==OFC is predominantly associated with (learned) valuation of (reinforcing) stimuli, but there is evidence of a distinct process in ACC (which projects anatomically to premotor regions) of value encoding for reinforced actions, and ACC sulcus may be required for learning of action values<ref>Kennerley SW, Walton ME, Behrens TEJ, Buckley MJ, Rushworth MFS. Optimal decision-making and the anterior cingulate cortex. Nature Neuroscience. 2006;9: 940– 947.</ref>