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ACC

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The anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex, that resembles a "collar" form around the corpus callosum, the fibrous bundle that relays neural signals between the right and left cerebral hemispheres of the brain. It consists of Brodmann areas 24, 32 and 33. It appears to play a role in a wide variety of autonomic functions, such as regulating blood pressure and heart rate, as well as rational cognitive functions, such as reward anticipation, decision making, empathy[1] and emotion.[2][3]

In decision making it is thought to detect conflicts between two deductions[4][5] and evaluating the rewards of actions[6]. On the integration of these finding please read this article.

Medial surface of left cerebral hemisphere, with anterior cingulate highlighted.
Medial surface of left cerebral hemisphere, with anterior cingulate highlighted.


In order to resolve an emotional conflict the rostalACC inhibits the amygdala (or FFFF mechanism)[7]. This is strengthing by the findings that in panic disorder, the volume of the the ACC is reduced, [8] . When the ACC (ACcd) has deficient in activation, there seem to be more impolsivity in ADHD compered to control group[9]. When anticipating pain, women domnstrate more activation of the ACC[10].

Liberals have higher ACC gray volume[11]. ACC is connected to conflict resultion (rACC to social conflict and dACC to non-social conflict). Reward valence modulates conflict-driven attentional adaptation in the ACC[12]. Greater liberalism was associated with stronger conflict-related anterior cingulate activity, suggesting greater neurocognitive sensitivity to cues for altering a habitual response pattern[13].

The ACC is important for responce time, therefore it was suggested that the ACC is related to "global energizing factor"[14]

dorsal ACC

Hypotheses about its function include guiding reward-based decision making[15], monitoring for conflict between competing responses[16] and predicting task difficulty[17]. Precise mechanisms of dACC function remain unknown. It was found that dACC is involved in adapting behaviour.[18].


It is thought that the dorsal ACC is primarly involved in cognitive processing[19]. It is part of the learning mechanism, that learn the positive and negative outcomes of actions in neutral tasks[20][21][22][23] and with correlation with rostral ACC, it is involved in emotional learning. It is also a reward mechanism, that gives "globals enrgizing factor", to actions that in the past seems to be rewarding[24]. Rats with lisions in the ACC, prefer less effortful mission with less reward, to tasks with more effortful with more reward[25].The ACC motivation mechanism is dependent on dopamin[26][27]. The Meutation in Dopamin receptor D2 may lower the amount of dopamin recived by the ACC, thus it may be the cause that make people with Atention Deficit Disorder (ADD), have lack of motivation to engage in effortful actions and decision making.

A Role for the Human Dorsal Anterior Cingulate Cortex in Fear Expression, 2007 - dACC has a major role in fear expression. When electrode stimulus was introduced to the dACC during head operations, patients reported high level of anxiety, where as when the regions was removed, anxiety symptoms were reduced[28]. See also the page on fear.

Dorsal ACC decision making system

rostral ACC

Also called ventral ACC

It is thought that rostral ACC id involved in emotional processing[29]. Sadness enhances the experience of pain via neural activation in the anterior cingulate cortex and amygdala[30].The Rostral Anterior Cingulate Cortex Modulates the Efficiency of Amygdala-Dependent Fear Learning[31].

It seems that rostral ACC is in the side of the critique[32] and have negative feedback on selection of actions. it is highly active in depression[33]. rACC is correlated with error detection[34][35]. It is used in emotional conflicts[36] but not with neutral conflicts[37][38][39].

rACC is negatively correlated with amygdala activity in conflict resolution tasks. it is suggested that the rACC down-regulate the amygdala[40]. (And may reduce anger or anxiety?)


Contents

Further readings

Other close areas

  • Theory of cognitive dissonance[42]

References

  1. ↑ http://ccare.stanford.edu/node/89
  2. ↑ Decety, J., & Jackson, P.L. (2004). The functional architecture of human empathy. Behavioral and Cognitive Neuroscience Reviews, 3, 71-100.
  3. ↑ Jackson P.L., Brunet E., Meltzoff A.N., Decety J., 2006 Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain: An event-related fMRI study, Neuropsychologia, 44, pp. 752–61
  4. ↑ Neurocognitive correlates of liberalism and conservatism, 2007, Amodio et al. Nature neuroscience (Summery in Hebrew)
  5. ↑ Jin Fan, Patrick R. Hof, Kevin G. Guise, John A. Fossella and Michael I. Posner, The Functional Integration of the Anterior Cingulate Cortex during Conflict Processing, Cerebral Cortex, Volume 18 Issue 4, p. 796-805.
  6. ↑ Kennerley et al., Optimal decision making and the anterior cingulate cortex, Nature Neuroscience 9, 940 - 947 (2006)
  7. ↑ Amit Etkin, Tobias Egner, Daniel M. Peraza, Eric R. Kandel and Joy Hirsch, Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala, Neuron 51, 1–12, September 7, 2006
  8. ↑ Takeshi et al., Anterior cingulate cortex volume reduction in patients with panic disorder, Psychiatry and Clinical Neurosciences 2008; 62: 322–330
  9. ↑ low ACcd activity and ADHD impulsivity, 1999
  10. ↑ Gender difrences in ACC before pain, 2005
  11. ↑ Kanai R, Feilden T, Firth C, Rees G (2011) Political orientations are correlated with brain structure in young adults. Curr Biol 21: 677–680.
  12. ↑ van Steenbergen, Guido P.H. Band and Bernhard Hommel, Reward valence modulates conflict-driven attentional adaptation: Electrophysiological evidence, 2012
  13. ↑ Amodio, D. M., Jost, J. T., Master, S. L., & Yee, C. M. (2007). Neurocognitive correlates of liberalism and conservatism. Nature neuroscience, 10(10), 1246-1247.
  14. ↑ Stuss, Donald T., Michael P. Alexander, Tim Shallice, Terence W. Picton, Malcolm A. Binns, Ronald Macdonald, Agnes Borowiec, and Douglas I. Katz. "Multiple frontal systems controlling response speed." Neuropsychologia 43, no. 3 (2005): 396-417.
  15. ↑ illiams, Z. M., Bush, G., Rauch, S. L., Cosgrove, G. R. & Eskandar, E. N. Human anterior cingulate neurons and the integration of monetary reward with motor responses. Nature Neurosci.7, 1370–1375 (2004).
  16. ↑ otvinick, M., Nystrom, L. E., Fissell, K., Carter, C. S. & Cohen, J. D. Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 402, 179–181 (1999)
  17. ↑ rown, J. W. & Braver, T. S. Learned predictions of error likelihood in the anterior cingulate cortex. Science 307, 1118–1121 (2005)
  18. ↑ Sheth, Sameer A., Matthew K. Mian, Shaun R. Patel, Wael F. Asaad, Ziv M. Williams, Darin D. Dougherty, George Bush, and Emad N. Eskandar. "Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation." Nature (2012).
  19. ↑ Bush G, Luu P & Posner MI, Cognotve and emotional influances in the anterior cingulate cotrex, Trends. Cogn. Sci. 4, 215-222 (2000)
  20. ↑ Botvinick M; Nystrom LE; Fissell K; Carter CS; Cohen JD: Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 1999; 402:179—181
  21. ↑ Kerns JG; Cohen JD; MacDonald AW 3rd; Cho RY; Stenger VA; Carter CS: Anterior cingulate conflict monitoring and adjustments in control. Science 2004; 303:1023—1026
  22. ↑ Carter CS; Macdonald AM; Botvinick M; Ross LL; Stenger VA; Noll D; Cohen JD: Parsing executive processes: strategic vs evaluative functions of the anterior cingulate cortex. Proc Natl Acad Sci USA 2000; 97:1944—1948
  23. ↑ Egner T; Hirsch J: The neural correlates and functional integration of cognitive control in a Stroop task. Neuroimage 2005; 24:539—547
  24. ↑ Struss DT et al.,2005, Multiple frontal systems controlling response speed, Neuropshichologia, 43: 396-417
  25. ↑ Walton ME at al, 2003, Fanctional specilization within medial frontal cortex of the antirior cingulate for evaluating effort-related decisions, J Neurosci, 23: 6475-6479
  26. ↑ Assadi SM, Yucel M & Pantelis C, 2009, Dopamin Modulates neural netowrks involved in effort-based decision making, Neurosci Biobehav, 33: 383-393
  27. ↑ Alexander MP, 2001, Chronic akinetic mutism after mesanphilic-diancphelick infraction: remediated with dopaminergic medications, Neurohabil Nural Repai, 15:151-156
  28. ↑ Meyer G, McElhaney M, Martin W, McGraw CP (1973): Stereotactic cin- gulotomy with results of acute stimulation and serial psychological testing, In: Laitinen LV, Livingston KE, editors. Surgical Approaches in Psychiatry. Lancaster, United Kingdom: MTP, Baltimore, 39 –58.
  29. ↑ Bush G, Luu P & Posner MI, Cognotve and emotional influances in the anterior cingulate cotrex, Trends. Cogn. Sci. 4, 215-222 (2000)
  30. ↑ [ http://www.sciencedirect.com/science/article/pii/S1053811909012658Atsou et al., Sadness enhances the experience of pain via neural activation in the anteriorcingulatecortex and amygdala: An fMRI study, 2009]
  31. ↑ Bissieree et al., The Rostral Anterior Cingulate Cortex Modulates the Efficiency of Amygdala-Dependent Fear Learning, 2008
  32. ↑ Etkin et al., Emotional processing in anterior cingulate and medial prefrontal cortex, 2011
  33. ↑ Wagner G, Sinsel E, Sobanski T, et al. Cortical inefficiency in patients with unipolar depression: an event-related FMRI study with the Stroop task. Biol Psychiatry 2006;59:958-65.
  34. ↑ Polli et al, Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission
  35. ↑ Kiehl et al, Error processing and the rostral anterior cingulate: An event-related fMRI study, 2000
  36. ↑ Etkin A et al.,Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala, Neuron, Volume 51, Issue 6, 871-882, 21 September 2006
  37. ↑ Martin E. Maier, Impaired Conflict Adaptation in an Emotional Task Context following Rostral Anterior Cingulate Cortex Lesions in Humans, 2012
  38. ↑ Egner T; Etkin A; Gale S; Hirsch J: Dissociable neural systems resolve conflict from emotional versus nonemotional distracters. Cereb Cortex 2008; 18:1475—1484
  39. ↑ Etkin A; Egner T; Peraza DM; Kandel ER; Hirsch J: Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 2006; 51:871—882
  40. ↑ Etkin, A et al. Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala, 2006
  41. ↑ Martino et al., Functional Brain Correlates of Social and Non-Social Processes in Autism Spectrum Disorders: an ALE Meta-Analysis, 2009
  42. ↑ Festinger, L. (1957). A theory ofcognitive dissonance. Evanston, IL: Row, Peterson
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