DACC
Hypotheses about its function include guiding reward-based decision making[1], monitoring for conflict between competing responses[2] and predicting task difficulty[3]. Precise mechanisms of dACC function remain unknown. It was found that dACC is involved in adapting behaviour.[4].
It is thought that the dorsal ACC is primarly involved in cognitive processing[5]. It is part of the learning mechanism, that learn the positive and negative outcomes of actions in neutral tasks[6][7][8][9] and with correlation with rostral ACC, it is involved in emotional learning. It is also a reward mechanism, that gives "globals enrgizing factor", to actions that in the past seems to be rewarding[10]. Rats with lisions in the ACC, prefer less effortful mission with less reward, to tasks with more effortful with more reward[11].The ACC motivation mechanism is dependent on dopamin[12][13]. The Meutation in Dopamin receptor D2 may lower the amount of dopamin recived by the ACC, thus it may be the cause that make people with Atention Deficit Disorder (ADD), have lack of motivation to engage in effortful actions and decision making.
A Role for the Human Dorsal Anterior Cingulate Cortex in Fear Expression, 2007 - dACC has a major role in fear expression. When electrode stimulus was introduced to the dACC during head operations, patients reported high level of anxiety, where as when the regions was removed, anxiety symptoms were reduced[14]. See also the page on fear.
References
- ↑ illiams, Z. M., Bush, G., Rauch, S. L., Cosgrove, G. R. & Eskandar, E. N. Human anterior cingulate neurons and the integration of monetary reward with motor responses. Nature Neurosci.7, 1370–1375 (2004).
- ↑ otvinick, M., Nystrom, L. E., Fissell, K., Carter, C. S. & Cohen, J. D. Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 402, 179–181 (1999)
- ↑ rown, J. W. & Braver, T. S. Learned predictions of error likelihood in the anterior cingulate cortex. Science 307, 1118–1121 (2005)
- ↑ Sheth, Sameer A., Matthew K. Mian, Shaun R. Patel, Wael F. Asaad, Ziv M. Williams, Darin D. Dougherty, George Bush, and Emad N. Eskandar. "Human dorsal anterior cingulate cortex neurons mediate ongoing behavioural adaptation." Nature (2012).
- ↑ Bush G, Luu P & Posner MI, Cognotve and emotional influances in the anterior cingulate cotrex, Trends. Cogn. Sci. 4, 215-222 (2000)
- ↑ Botvinick M; Nystrom LE; Fissell K; Carter CS; Cohen JD: Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 1999; 402:179—181
- ↑ Kerns JG; Cohen JD; MacDonald AW 3rd; Cho RY; Stenger VA; Carter CS: Anterior cingulate conflict monitoring and adjustments in control. Science 2004; 303:1023—1026
- ↑ Carter CS; Macdonald AM; Botvinick M; Ross LL; Stenger VA; Noll D; Cohen JD: Parsing executive processes: strategic vs evaluative functions of the anterior cingulate cortex. Proc Natl Acad Sci USA 2000; 97:1944—1948
- ↑ Egner T; Hirsch J: The neural correlates and functional integration of cognitive control in a Stroop task. Neuroimage 2005; 24:539—547
- ↑ Struss DT et al.,2005, Multiple frontal systems controlling response speed, Neuropshichologia, 43: 396-417
- ↑ Walton ME at al, 2003, Fanctional specilization within medial frontal cortex of the antirior cingulate for evaluating effort-related decisions, J Neurosci, 23: 6475-6479
- ↑ Assadi SM, Yucel M & Pantelis C, 2009, Dopamin Modulates neural netowrks involved in effort-based decision making, Neurosci Biobehav, 33: 383-393
- ↑ Alexander MP, 2001, Chronic akinetic mutism after mesanphilic-diancphelick infraction: remediated with dopaminergic medications, Neurohabil Nural Repai, 15:151-156
- ↑ Meyer G, McElhaney M, Martin W, McGraw CP (1973): Stereotactic cin- gulotomy with results of acute stimulation and serial psychological testing, In: Laitinen LV, Livingston KE, editors. Surgical Approaches in Psychiatry. Lancaster, United Kingdom: MTP, Baltimore, 39 –58.